Current Issue : July-September Volume : 2025 Issue Number : 3 Articles : 5 Articles
A promising strategy to improve the gut microbiome in hypertension is to target the gut microbiota. This study evaluated the effects of a potential nutraceutical product composed of three strains of Limosilactobacillus (L.) fermentum, quercetin, and resveratrol on the intestinal microbiome of healthy and hypertensive subjects. The nutraceutical product consisting of strains of L. fermentum 139, 263 and 296, fructooligosaccharides (200 mg), quercetin (160 mg), and resveratrol (150 mg) (LfQR) was added to the in vitro fecal fermentation process occurring for 48 h. Fecal samples of healthy and hypertensive subjects were allocated into four groups: (i) healthy controls (CTL); (ii) healthy controls with the addition of LfQR (CTL + LfQR); (iii) hypertensive (HTN) subjects; and (iv) hypertensive subjects with the addition of LfQR (HTN + LfQR). The diversity and composition of the fecal microbiota and the production of microbial metabolites were evaluated. CTL and HTN groups exhibited a distinct gut microbiota composition, as shown by the β-diversity assessment. The addition of the potentially nutraceutical-modulated β-diversity was similar between CTL and HTN groups, suggesting a similar gut microbiome composition after nutraceutical addition. The addition of the nutraceutical product increased the relative abundance of Enterobacteriaceae in the CTL group and that of Lachnospiraceae in the HTN group. The nutraceutical media showed higher levels of sugars (maltose, fructose, and glucose), lactic acid, ethanol, succinic acid, and acetic acid compared to the CTL and HTN media. Although the results are heterogeneous between healthy and hypertensive fermentation media, it was demonstrated that the nutraceutical formulation can modulate the intestinal microbiota and its metabolic activity....
Introduction: Bioactive compounds and whole foods have emerged as promising interventions to address gut microbiota dysbiosis linked to obesity. Compounds such as berberine and coenzyme Q10 are well-recognized for their roles in managing metabolic syndrome and exerting antioxidant effects, while beet pulp, rich in fiber and antioxidants, enhances gut health through additional prebiotic benefits. Methods: This study evaluated the effects of a nutraceutical supplement, Slim, on the modulation of gut microbiota in obese mice induced by a high-fat diet. Results: Our results demonstrated that Slim supplementation significantly improved lipid metabolism, reshaped colon histomorphology, and decreased levels of Mucispirillum schaedleri, which were correlated with VLDL-c and triglycerides. Discussion: We suggest these effects are driven by a duplibiotic effect, resulting from the synergistic action of the bioactive compounds....
Background: Medicago sativa has been used as food by both humans and animals. However, its nutraceutical properties have yet to be clarified, and thus, the present study aimed to evaluate the biological properties of M. sativa. Methods: Total phenolic and flavonoid contents of the methanolic extract of M. sativa were determined using Folin-Ciocalteu colorimetric and Woisky-Salatino methods. The antioxidant and antimicrobial activities of this plant were examined using in vitro assays. The anti-malarial and anti-platelet aggregation activities were evaluated by heme detoxification and turbidometric methods, respectively. Cytotoxicity and brine shrimp lethality assays were used for toxicological evaluations. Results: M. sativa methanolic extract had 38.7±0.57 mg of gallic acid equivalents/g extract and 27.6±0.31 mg rutin equivalents/g extract concentration of phenolic and flavonoid contents. The strongest antibacterial activity was against Staphylococcus aureus and Salmonella enterica with Minimum Inhibitory Concentration (MIC) of 62.5 mg/ mL, and 62.5 mg/mL, respectively. The extract showed antioxidant activity with half-maximal inhibitory concentration (IC50) of 179.1 μg/m. Regarding the anti-platelet activity, the extract with a concentration of 20 mg/mL inhibited the arachidonic acid pathway by 23.70%. The brine shrimp lethality assay results showed that LC50 of M. sativa extract was 17.62074 μg/mL; while the cytotoxicity assay revealed that the extract at concentration of 10000 μg/mL was toxic for human dermal fibroblasts and corneal epithelial cells. Conclusion: Our study elucidated the antibacterial, antioxidant, and antiplatelet aggregation properties of the methanolic extract of M. sativa....
Nutraceuticals-including resveratrol (RSV), curcumin (CUR), piperine (PPR), and quercetin (QUE)-exhibit dual therapeutic and toxicological profiles, are necessitating balanced risk–benefit evaluation. This review synthesizes evidence from about 120 preclinical/clinical studies sourced from PubMed, Scopus, and Web of Science using keywords (e.g., nutraceutical-drug interactions, bioavailability, CYP/P-gp modulation), prioritizing recent advances (2015–2024) alongside seminal works to contextualize mechanisms. Studies were selected based on methodological rigor, clinical relevance, and mechanistic insights into protective effects (antioxidant, anti-inflammatory, anticancer) and risks (organ toxicity, pro-oxidant activity, drug interactions). Key findings highlight PPR’s bioavailability-enhancing and neuroprotective properties, yet its inhibition of CYP3A4/P-gp elevates toxicity risks for carbamazepine (68.7% ↑ plasma concentration) and warfarin. CUR demonstrates hepatoprotective benefits but alters cardiovascular drug pharmacokinetics (e.g., amlodipine) and induces oxidative stress at high doses. RSV and QUE improve cardiovascular/neurological outcomes but interact with chemotherapeutics (RSV ↓ drug resistance via apoptosis; QUE ↑ methotrexate efficacy via anti-inflammatory synergy). Critical risks include reproductive toxicity (PPR >10 mg/kg), neurocognitive deficits (high-dose CUR), and CYP3A4-mediated interactions (QUE + cyclosporine). Nanotechnology-driven formulations (e.g., CUR/PPR nanoemulsions) mitigate risks by enhancing stability and enabling targeted delivery, though rigorous safety validation remains essential. This review underscores the need for evidencebased guidelines to optimize nutraceutical use in polypharmacy populations, emphasizing interdisciplinary collaboration to manage interactions. Innovations like nanoencapsulation could transition nutraceuticals from supplements to precision medicine adjuvants, pending resolution of dose–response ambiguities and longterm safety gaps through targeted research....
The flower buds of Syzygium nervosum are traditional edible and medicinal plant materials for the treatment of inflammation and stomach disorders. With rising demand for natural products in food and cosmetics, the nutraceutical and nutricosmetic potential of the flower buds has been evaluated in this work. The antioxidant activity of ethanol and water extracts of S. nervosum flower buds were detected through free radical scavenging (DPPH, ·OH, and ABTS) assays, and their inhibitory effects on tyrosinase and elastase enzymes were also evaluated. The ethanol extract (SNEE) exhibited stronger antioxidant activity and superior inhibitory effects on both enzymes compared with the water extract (SNWE), highlighting its potential for anti-aging and skin-whitening applications. Meanwhile, the LC-QTOF-MS was employed for the identification of key chemical molecules responsible for the nutricosmetic properties. Moreover, the enzyme inhibitory mechanisms of the flower bud extracts were further elucidated using inhibition kinetics and molecular docking methods. This research underscores the promising nutraceutical and nutricosmetic potential of S. nervosum flower buds so as to offer important information for further developing the edible flower resource as skin feeding bioactive ingredients....
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